Multifunctional protein CAD

BE0002227ProteinHumansCAD

Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). It is acted on by 3 drugs in DrugBank.

Gene name
CAD
UniProtKB entry
P27708Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
2,225 residues · 242,982 Da
Also known as
Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase

Resolves to

Protein
UniProtP27708UniProt namePYR1_HUMAN
Gene
HGNCHGNC:1424NCBI Gene790GenBank1228049GeneCardsCAD
Pharmacology
KEGGhsa:790
Structure
PDB4BY3PDB4C6BPDB4C6C
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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30GO termsFunction, process and component, as structured annotations
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9Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Multifunctional protein CAD, how selective are they, and which programs against it are still in active trials?

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