Adenylosuccinate synthetase isozyme 2

BE0002228ProteinHumansADSS2

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. It is acted on by 2 drugs in DrugBank.

Gene name
ADSS2
UniProtKB entry
P30520Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
456 residues · 50,097 Da
Also known as
6.3.4.4 · Adenylosuccinate synthetase, acidic isozyme · Adenylosuccinate synthetase, liver isozyme · ADSS · AdSS 2

Resolves to

Protein
UniProtP30520UniProt namePURA2_HUMAN
Gene
HGNCHGNC:292NCBI Gene159GenBank415849GeneCardsADSS2
Pharmacology
KEGGhsa:159
Structure
PDB2V40
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenylosuccinate synthetase isozyme 2, how selective are they, and which programs against it are still in active trials?

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