Aspartate--tRNA ligase, mitochondrial

BE0002229ProteinHumansDARS2

Catalyzes the attachment of aspartate to tRNA(Asp) in a two-step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp). It is acted on by 1 drug in DrugBank.

Gene name
DARS2
UniProtKB entry
Q6PI48Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
645 residues · 73,562 Da
Also known as
6.1.1.12 · Aspartyl-tRNA synthetase · AspRS

Resolves to

Protein
UniProtQ6PI48UniProt nameSYDM_HUMAN
Gene
HGNCHGNC:25538NCBI Gene55157GenBank56203852GeneCardsDARS2
Pharmacology
KEGGhsa:55157
Structure
PDB4AH6
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aspartate--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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