Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

BE0002237ProteinHumansGATB

Catalytic subunit of the mitochondrial Glu-tRNA(Gln) amidotransferase complex GatCAB (Probable). It is acted on by 1 drug in DrugBank.

Gene name
GATB
UniProtKB entry
O75879Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
557 residues · 61,864 Da
Also known as
6.3.5.7 · Cytochrome oxidase assembly factor PET112 homolog · Glu-AdT subunit B · PET112 · PET112-like

Resolves to

Protein
UniProtO75879UniProt nameGATB_HUMAN
Gene
HGNCHGNC:8849NCBI Gene5188GenBank3599964GeneCardsGATB
Pharmacology
KEGGhsa:5188
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial, how selective are they, and which programs against it are still in active trials?

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