Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

BE0002238ProteinHumansGFPT2

Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:35229715). It is acted on by 1 drug in DrugBank.

Gene name
GFPT2
UniProtKB entry
O94808Swiss-Prot
Residues / weight
682 residues · 76,930 Da
Also known as
2.6.1.16 · D-fructose-6-phosphate amidotransferase 2 · GFAT 2 · GFAT2 · Glutamine:fructose-6-phosphate amidotransferase 2

Resolves to

Protein
UniProtO94808UniProt nameGFPT2_HUMAN
Gene
HGNCHGNC:4242NCBI Gene9945GenBank4239883GeneCardsGFPT2
Pharmacology
KEGGhsa:9945
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2, how selective are they, and which programs against it are still in active trials?

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