Protein-glutamine gamma-glutamyltransferase K

BE0002241ProteinHumansTGM1

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins (PubMed:7629111, PubMed:8824274, PubMed:26220141, PubMed:20663883). It is acted on by 2 drugs in DrugBank.

Gene name
TGM1
UniProtKB entry
P22735Swiss-Prot
Cellular location
Cell membrane
Residues / weight
817 residues · 89,786 Da
Also known as
2.3.2.13 · Epidermal TGase · KTG · TG(K) · TGase K

Resolves to

Protein
UniProtP22735UniProt nameTGM1_HUMAN
Gene
HGNCHGNC:11777NCBI Gene7051GenBank1256959GeneCardsTGM1
Pharmacology
KEGGhsa:7051
Structure
PDB2XZZ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein-glutamine gamma-glutamyltransferase K, how selective are they, and which programs against it are still in active trials?

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