Acyl-CoA 6-desaturase

BE0002246ProteinHumansFADS2

Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase... It is acted on by 3 drugs in DrugBank.

Gene name
FADS2
UniProtKB entry
O95864Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
444 residues · 52,259 Da
Also known as
1.14.19.3 · D6D · Delta-6 desaturase · Delta(6) desaturase · Delta(6) fatty acid desaturase

Resolves to

Protein
UniProtO95864UniProt nameFADS2_HUMAN
Gene
HGNCHGNC:3575NCBI Gene9415GenBank4406528GeneCardsFADS2
Pharmacology
KEGGhsa:9415
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acyl-CoA 6-desaturase, how selective are they, and which programs against it are still in active trials?

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