Very long chain fatty acid elongase 4

BE0002247ProteinHumansELOVL4

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. It is acted on by 2 drugs in DrugBank.

Gene name
ELOVL4
UniProtKB entry
Q9GZR5Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
314 residues · 36,829 Da
Also known as
2.3.1.199 · 3-keto acyl-CoA synthase ELOVL4 · Elongation of very long chain fatty acids protein 4 · ELOVL FA elongase 4 · ELOVL fatty acid elongase 4

Resolves to

Protein
UniProtQ9GZR5UniProt nameELOV4_HUMAN
Gene
HGNCHGNC:14415NCBI Gene6785GenBank12044051GeneCardsELOVL4
Pharmacology
KEGGhsa:6785
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Very long chain fatty acid elongase 4, how selective are they, and which programs against it are still in active trials?

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