1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

BE0002250ProteinHumansCYP24A1

A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. It is acted on by 8 drugs in DrugBank.

Gene name
CYP24A1
UniProtKB entry
Q07973Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
514 residues · 58,875 Da
Also known as
1.14.15.16 · 24-OHase · CYP24 · Cytochrome P450 24A1 · Cytochrome P450-CC24

Resolves to

Protein
UniProtQ07973UniProt nameCP24A_HUMAN
Gene
HGNCHGNC:2602NCBI Gene1591GenBank306704GeneCardsCYP24A1
Pharmacology
IUPHAR/GtoPdb1365KEGGhsa:1591
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
2Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
2Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
24+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In