Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

BE0002254ProteinHumansSDHB

Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:26925370, PubMed:27604842). It is acted on by 2 drugs in DrugBank.

Gene name
SDHB
UniProtKB entry
P21912Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
280 residues · 31,629 Da
Also known as
1.3.5.1 · Ip · Iron-sulfur subunit of complex II · Malate dehydrogenase [quinone] iron-sulfur subunit · SDH

Resolves to

Protein
UniProtP21912UniProt nameSDHB_HUMAN
Gene
HGNCHGNC:10681NCBI Gene6390GenBank665925GeneCardsSDHB
Pharmacology
KEGGhsa:6390
Structure
PDB7KCLPDB7KCMPDB7KLU
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial, and which indications are they being tested in?

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