Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

BE0002255ProteinHumansSUCLG1

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:34492704,...

Gene name
SUCLG1
UniProtKB entry
P53597Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
346 residues · 36,250 Da
Also known as
6.2.1.4 · 6.2.1.5 · Itaconyl--CoA ligase [ADP/GDP-forming] subunit alpha · Malyl--CoA ligase [ADP/GDP-forming] subunit alpha · SCS-alpha

Resolves to

Protein
UniProtP53597UniProt nameSUCA_HUMAN
Gene
HGNCHGNC:11449NCBI Gene8802GenBank9409794GeneCardsSUCLG1
Pharmacology
KEGGhsa:8802
Structure
PDB6G4QPDB6WCVPDB7MSR

What you can answer from here — as of September 03, 2024

8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, and which indications are they being tested in?

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