Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

BE0002260ProteinHumansSUCLA2

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282, PubMed:34492704, PubMed:40108300).

Gene name
SUCLA2
UniProtKB entry
Q9P2R7Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
463 residues · 50,317 Da
Also known as
6.2.1.5 · A-SCS · ATP-specific succinyl-CoA synthetase subunit beta · Itaconyl--CoA ligase [ADP-forming] subunit beta · Malyl--CoA ligase [ADP-forming] subunit beta

Resolves to

Protein
UniProtQ9P2R7UniProt nameSUCB1_HUMAN
Gene
HGNCHGNC:11448NCBI Gene8803GenBank7328935GeneCardsSUCLA2
Pharmacology
KEGGhsa:8803
Structure
PDB6G4QPDB9SWJ

What you can answer from here — as of September 03, 2024

8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, and which indications are they being tested in?

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