Diacylglycerol kinase delta

BE0002297ProteinHumansDGKD

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). It is acted on by 1 drug in DrugBank.

Gene name
DGKD
UniProtKB entry
Q16760Swiss-Prot
Cellular location
Membrane, clathrin-coated pit
Residues / weight
1,214 residues · 134,524 Da
Also known as
130 kDa diacylglycerol kinase · 2.7.1.107 · DAG kinase delta · DGK-delta · Diglyceride kinase delta

Resolves to

Protein
UniProtQ16760UniProt nameDGKD_HUMAN
Gene
HGNCHGNC:2851NCBI Gene8527GenBank22773821GeneCardsDGKD
Pharmacology
KEGGhsa:8527
Structure
PDB1R79PDB3BQ7
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Diacylglycerol kinase delta, how selective are they, and which programs against it are still in active trials?

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