Phosphatidylserine synthase 2

BE0002299ProteinHumansPTDSS2

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine to form phosphatidylserine (PubMed:19014349). It is acted on by 1 drug in DrugBank.

Gene name
PTDSS2
UniProtKB entry
Q9BVG9Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
487 residues · 56,253 Da
Also known as
2.7.8.29 · PSS-2 · PSS2 · PtdSer synthase 2 · Serine-exchange enzyme II

Resolves to

Protein
UniProtQ9BVG9UniProt namePTSS2_HUMAN
Gene
HGNCHGNC:15463NCBI Gene81490GenBank21740008GeneCardsPTDSS2
Pharmacology
KEGGhsa:81490
Structure
PDB9N0X
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylserine synthase 2, how selective are they, and which programs against it are still in active trials?

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