Sphingomyelin phosphodiesterase 3

BE0002301ProteinHumansSMPD3

Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. It is acted on by 2 drugs in DrugBank.

Gene name
SMPD3
UniProtKB entry
Q9NY59Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
655 residues · 71,080 Da
Also known as
3.1.4.12 · Neutral sphingomyelinase 2 · Neutral sphingomyelinase II · nSMase-2 · nSMase2

Resolves to

Protein
UniProtQ9NY59UniProt nameNSMA2_HUMAN
Gene
HGNCHGNC:14240NCBI Gene55512GenBank8247250GeneCardsSMPD3
Pharmacology
KEGGhsa:55512
Structure
PDB5UVG
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingomyelin phosphodiesterase 3, how selective are they, and which programs against it are still in active trials?

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