Vesicular inhibitory amino acid transporter

BE0002308ProteinHumansSLC32A1

Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. It is acted on by 1 drug in DrugBank.

Gene name
SLC32A1
UniProtKB entry
Q9H598Swiss-Prot
Cellular location
Cytoplasmic vesicle membrane
Residues / weight
525 residues · 57,415 Da
Also known as
GABA and glycine transporter · hVIAAT · Solute carrier family 32 member 1 · Vesicular GABA transporter · VGAT

Resolves to

Protein
UniProtQ9H598UniProt nameVIAAT_HUMAN
Gene
HGNCHGNC:11018NCBI Gene140679GenBank17975777GeneCardsSLC32A1
Pharmacology
IUPHAR/GtoPdb1133KEGGhsa:140679
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
14GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
8+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Vesicular inhibitory amino acid transporter, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In