Tryptophan--tRNA ligase, mitochondrial

BE0002311ProteinHumansWARS2

Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp). It is acted on by 1 drug in DrugBank.

Gene name
WARS2
UniProtKB entry
Q9UGM6Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
360 residues · 40,146 Da
Also known as
(Mt)TrpRS · 6.1.1.2 · TrpRS · Tryptophanyl-tRNA synthetase

Resolves to

Protein
UniProtQ9UGM6UniProt nameSYWM_HUMAN
Gene
HGNCHGNC:12730NCBI Gene10352GenBank6572289GeneCardsWARS2
Pharmacology
KEGGhsa:10352
Structure
PDB5EKD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptophan--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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