Probable cysteine--tRNA ligase, mitochondrial

BE0002312ProteinHumansCARS2

Mitochondrial cysteine-specific aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). It is acted on by 1 drug in DrugBank.

Gene name
CARS2
UniProtKB entry
Q9HA77Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
564 residues · 62,223 Da
Also known as
6.1.1.16 · CysRS · Cysteinyl-tRNA synthetase

Resolves to

Protein
UniProtQ9HA77UniProt nameSYCM_HUMAN
Gene
HGNCHGNC:25695NCBI Gene79587GenBank10433519GeneCardsCARS2
Pharmacology
KEGGhsa:79587
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Probable cysteine--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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