Short-chain dehydrogenase/reductase 3

BE0002319ProteinHumansDHRS3

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH (PubMed:9705317). It is acted on by 1 drug in DrugBank.

Gene name
DHRS3
UniProtKB entry
O75911Swiss-Prot
Cellular location
Membrane
Residues / weight
302 residues · 33,548 Da
Also known as
1.1.1.300 · DD83.1 · RDH17 · Retinal short-chain dehydrogenase/reductase 1 · Retinol dehydrogenase 17

Resolves to

Protein
UniProtO75911UniProt nameDHRS3_HUMAN
Gene
HGNCHGNC:17693NCBI Gene9249GenBank3450828GeneCardsDHRS3
Pharmacology
KEGGhsa:9249
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Short-chain dehydrogenase/reductase 3, how selective are they, and which programs against it are still in active trials?

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