Lipoyl synthase, mitochondrial

BE0002327ProteinHumansLIAS

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. It is acted on by 1 drug in DrugBank.

Gene name
LIAS
UniProtKB entry
O43766Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
372 residues · 41,911 Da
Also known as
2.8.1.8 · LAS · Lip-syn · Lipoate synthase · Lipoic acid synthase

Resolves to

Protein
UniProtO43766UniProt nameLIAS_HUMAN
Gene
HGNCHGNC:16429NCBI Gene11019GenBank23958222GeneCardsLIAS
Pharmacology
KEGGhsa:11019
Structure
PDB8TRWPDB8TSKPDB8UGO
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lipoyl synthase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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