Asparaginyl-tRNA synthetase

BE0002338ProteinHumansNARS2

Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the asparagine amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis (PubMed:25385316). It is acted on by 1 drug in DrugBank.

Gene name
NARS2
UniProtKB entry
Q96I59Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
477 residues · 54,090 Da
Also known as
6.1.1.22 · AsnRS · Asparagine--tRNA ligase, mitochondrial · NARS2

Resolves to

Protein
UniProtQ96I59UniProt nameSYNM_HUMAN
Gene
HGNCHGNC:26274NCBI Gene79731GenBank39644781GeneCardsNARS2
Pharmacology
KEGGhsa:79731
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Asparaginyl-tRNA synthetase, how selective are they, and which programs against it are still in active trials?

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