Proteasome subunit beta type-1

BE0002347ProteinHumansPSMB1

Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. It is acted on by 4 drugs in DrugBank.

Gene name
PSMB1
UniProtKB entry
P20618Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
241 residues · 26,489 Da
Also known as
beta-6 · Macropain subunit C5 · Multicatalytic endopeptidase complex subunit C5 · Proteasome component C5 · Proteasome gamma chain

Resolves to

Protein
UniProtP20618UniProt namePSB1_HUMAN
Gene
HGNCHGNC:9537NCBI Gene5689GenBank220026GeneCardsPSMB1
Pharmacology
IUPHAR/GtoPdb2404KEGGhsa:5689
Structure
PDB4R3OPDB4R67PDB5A0Q
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proteasome subunit beta type-1, how selective are they, and which programs against it are still in active trials?

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