Proteasome subunit beta type-2

BE0002349ProteinHumansPSMB2

Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. It is acted on by 2 drugs in DrugBank.

Gene name
PSMB2
UniProtKB entry
P49721Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
201 residues · 22,836 Da
Also known as
beta-4 · Macropain subunit C7-I · Multicatalytic endopeptidase complex subunit C7-I · Proteasome component C7-I · Proteasome subunit beta-4

Resolves to

Protein
UniProtP49721UniProt namePSB2_HUMAN
Gene
HGNCHGNC:9539NCBI Gene5690GenBank565649GeneCardsPSMB2
Pharmacology
IUPHAR/GtoPdb2405KEGGhsa:5690
Structure
PDB4R3OPDB4R67PDB5A0Q
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proteasome subunit beta type-2, how selective are they, and which programs against it are still in active trials?

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