Voltage-dependent L-type calcium channel subunit beta-4

BE0002356ProteinHumansCACNB4

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the... It is acted on by 3 drugs in DrugBank.

Gene name: CACNB4
UniProtKB entry: O00305Swiss-Prot
Residues / weight: 520 residues · 58,169 Da
Also known as: CAB4 · CACNLB4 · Calcium channel voltage-dependent subunit beta 4

Resolves to

Protein

UniProtO00305UniProt nameCACB4_HUMAN

Gene

HGNCHGNC:1404NCBI Gene785GenBank2058727GeneCardsCACNB4

Pharmacology

KEGGhsa:785

Structure

PDB2D46

Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action

5GO termsFunction, process and component, as structured annotations

2Pfam domainsDomain architecture mapped to Pfam families and clans

18+ReferencesStructured and connected to the statements they support

Which approved drugs act on Voltage-dependent L-type calcium channel subunit beta-4, how selective are they, and which programs against it are still in active trials?

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