Voltage-dependent L-type calcium channel subunit beta-3

BE0002358ProteinHumansCACNB3

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). It is acted on by 3 drugs in DrugBank.

Gene name
CACNB3
UniProtKB entry
P54284Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
484 residues · 54,531 Da
Also known as
CAB3 · CACNLB3 · Calcium channel voltage-dependent subunit beta 3

Resolves to

Protein
UniProtP54284UniProt nameCACB3_HUMAN
Gene
HGNCHGNC:1403NCBI Gene784GenBank435135GeneCardsCACNB3
Pharmacology
KEGGhsa:784
Structure
PDB7MIXPDB7MIYPDB7UHF
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent L-type calcium channel subunit beta-3, how selective are they, and which programs against it are still in active trials?

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