Calcitonin gene-related peptide 2
Details
- Name
- Calcitonin gene-related peptide 2
- Kind
- protein
- Synonyms
- Beta-CGRP
- Beta-type CGRP
- CALC2
- Calcitonin gene-related peptide II
- CGRP-II
- Gene Name
- CALCB
- UniProtKB Entry
- P10092Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0011700|Calcitonin gene-related peptide 2 MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQM KASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGR RRRDLQA
- Number of residues
- 127
- Molecular Weight
- 13705.56
- Theoretical pI
- 10.73
- GO Classification
- Functionscalcitonin receptor bindingProcessesadenylate cyclase-activating G protein-coupled receptor signaling pathway / intracellular calcium ion homeostasis / regulation of cytosolic calcium ion concentrationComponentsextracellular space
- General Function
- CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role
- Specific Function
- calcitonin receptor binding
- Pfam Domain Function
- Calc_CGRP_IAPP (PF00214)
- Signal Regions
- 1-25
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0011701|Calcitonin gene-related peptide 2 (CALCB) ATGGGTTTCCGGAAGTTCTCCCCCTTCCTGGCTCTCAGTATCTTGGTCCTGTACCAGGCG GGCAGCCTCCAGGCGGCGCCATTCAGGTCTGCCCTGGAGAGCAGCCCAGACCCGGCCACA CTCAGTAAAGAGGACGCGCGCCTCCTGCTGGCTGCACTGGTGCAGGACTATGTGCAGATG AAGGCCAGTGAGCTGAAGCAGGAGCAGGAGACACAGGGCTCCAGCTCCGCTGCCCAGAAG AGAGCCTGCAACACTGCCACCTGTGTGACTCATCGGCTGGCAGGCTTGCTGAGCAGATCA GGGGGCATGGTGAAGAGCAACTTCGTGCCCACCAATGTGGGTTCCAAAGCCTTTGGCAGG CGCCGCAGGGACCTTCAAGCCTGA
- Chromosome Location
- 11
- Locus
- 11p15.2
- External Identifiers
Resource Link UniProtKB ID P10092 UniProtKB Entry Name CALCB_HUMAN GenBank Gene ID BC092468 GeneCard ID CALCB GenAtlas ID CALCB HGNC ID HGNC:1438 KEGG ID hsa:797 NCBI Gene ID 797 - General References
- Steenbergh PH, Hoppener JW, Zandberg J, Visser A, Lips CJ, Jansz HS: Structure and expression of the human calcitonin/CGRP genes. FEBS Lett. 1986 Dec 1;209(1):97-103. [Article]
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- Steenbergh PH, Hoppener JW, Zandberg J, Lips CJ, Jansz HS: A second human calcitonin/CGRP gene. FEBS Lett. 1985 Apr 22;183(2):403-7. [Article]
- Petermann JB, Born W, Chang JY, Fischer JA: Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord. J Biol Chem. 1987 Jan 15;262(2):542-5. [Article]
- Wimalawansa SJ, Morris HR, Etienne A, Blench I, Panico M, MacIntyre I: Isolation, purification and characterization of beta-hCGRP from human spinal cord. Biochem Biophys Res Commun. 1990 Mar 30;167(3):993-1000. [Article]
- Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Matsuo H, Eto T: Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. Biochem Biophys Res Commun. 1992 May 29;185(1):134-41. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Telcagepant investigational unknown target Details Eptinezumab approved, investigational yes target binderantibody Details Galcanezumab approved, investigational yes target antibody Details Fremanezumab approved, investigational yes target binderantibody Details