Neuromedin-K receptor

BE0002371ProteinHumansTACR3

Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P (PubMed:1312036, PubMed:37391393). It is acted on by 5 drugs in DrugBank.

Gene name
TACR3
UniProtKB entry
P29371Swiss-Prot
Cellular location
Cell membrane
Residues / weight
465 residues · 52,201 Da
Also known as
Neurokinin B receptor · NK-3 receptor · NK-3R · NK3R · NKR

Resolves to

Protein
UniProtP29371UniProt nameNK3R_HUMAN
Gene
HGNCHGNC:11528NCBI Gene6870GeneCardsTACR3
Pharmacology
IUPHAR/GtoPdb362KEGGhsa:6870
Structure
PDB8JBFPDB8JBGPDB8JBH
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuromedin-K receptor, how selective are they, and which programs against it are still in active trials?

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