Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

BE0002373ProteinHumansFNTA

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. It is acted on by 16 drugs in DrugBank.

Gene name
FNTA
UniProtKB entry
P49354Swiss-Prot
Residues / weight
379 residues · 44,408 Da
Also known as
2.5.1.58 · 2.5.1.59 · CAAX farnesyltransferase subunit alpha · FTase-alpha · GGTase-I-alpha

Resolves to

Protein
UniProtP49354UniProt nameFNTA_HUMAN
Gene
HGNCHGNC:3782NCBI Gene2339GeneCardsFNTA
Pharmacology
KEGGhsa:2339
Structure
PDB1JCQPDB1LD7PDB1LD8
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, how selective are they, and which programs against it are still in active trials?

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