Methionine--tRNA ligase

BE0002381ProteinStaphylococcus aureus (strain MRSA252)metG

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. It is acted on by 1 drug in DrugBank.

Gene name
metG
UniProtKB entry
Q6GJI1Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
657 residues · 74,897 Da
Also known as
6.1.1.10 · Methionyl-tRNA synthetase · MetRS · metS

Resolves to

Protein
UniProtQ6GJI1UniProt nameSYM_STAAR
Pharmacology
KEGGsar:SAR0491
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Methionine--tRNA ligase, and which indications are they being tested in?

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