Phosphatidylinositol 3-kinase regulatory subunit beta

BE0002383ProteinHumansPIK3R2

Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). It is acted on by 1 drug in DrugBank.

Gene name
PIK3R2
UniProtKB entry
O00459Swiss-Prot
Residues / weight
728 residues · 81,545 Da
Also known as
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta · PI3-kinase regulatory subunit beta · PI3-kinase subunit p85-beta · PI3K regulatory subunit beta · PtdIns-3-kinase regulatory subunit beta

Resolves to

Protein
UniProtO00459UniProt nameP85B_HUMAN
Gene
HGNCHGNC:8980NCBI Gene5296GeneCardsPIK3R2
Pharmacology
KEGGhsa:5296
Structure
PDB2KT1PDB2XS6PDB3MTT
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphatidylinositol 3-kinase regulatory subunit beta, and which indications are they being tested in?

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