NF-kappa-B essential modulator

BE0002394ProteinHumansIKBKG

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor (PubMed:14695475, PubMed:20724660, PubMed:21518757, PubMed:9751060). It is acted on by 2 drugs in DrugBank.

Gene name
IKBKG
UniProtKB entry
Q9Y6K9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
419 residues · 48,197 Da
Also known as
FIP-3 · FIP3 · I-kappa-B kinase subunit gamma · IkB kinase subunit gamma · IkB kinase-associated protein 1

Resolves to

Protein
UniProtQ9Y6K9UniProt nameNEMO_HUMAN
Gene
HGNCHGNC:5961NCBI Gene8517GeneCardsIKBKG
Pharmacology
KEGGhsa:8517
Structure
PDB2JVXPDB2JVYPDB3BRT
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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68+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NF-kappa-B essential modulator, and which indications are they being tested in?

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