Furin

BE0002397ProteinHumansFURIN

Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). It is acted on by 1 drug in DrugBank.

Gene name
FURIN
UniProtKB entry
P09958Swiss-Prot
Cellular location
Golgi apparatus, trans-Golgi network membrane
Residues / weight
794 residues · 86,677 Da
Also known as
3.4.21.75 · Dibasic-processing enzyme · FUR · PACE · Paired basic amino acid residue-cleaving enzyme

Resolves to

Protein
UniProtP09958UniProt nameFURIN_HUMAN
Gene
HGNCHGNC:8568NCBI Gene5045GeneCardsFURIN
Pharmacology
IUPHAR/GtoPdb2366KEGGhsa:5045
Structure
PDB4OMCPDB4OMDPDB4RYD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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33GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Furin, and which indications are they being tested in?

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