Potassium voltage-gated channel subfamily KQT member 4

BE0002399ProteinHumansKCNQ4

Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea (PubMed:10025409, PubMed:34767770). It is acted on by 3 drugs in DrugBank.

Gene name
KCNQ4
UniProtKB entry
P56696Swiss-Prot
Cellular location
Basal cell membrane
Residues / weight
695 residues · 77,100 Da
Also known as
KQT-like 4 · Potassium channel subunit alpha KvLQT4 · Voltage-gated potassium channel subunit Kv7.4

Resolves to

Protein
UniProtP56696UniProt nameKCNQ4_HUMAN
Gene
HGNCHGNC:6298NCBI Gene9132GeneCardsKCNQ4
Pharmacology
IUPHAR/GtoPdb563KEGGhsa:9132
Structure
PDB2OVCPDB4GOWPDB6B8L
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium voltage-gated channel subfamily KQT member 4, how selective are they, and which programs against it are still in active trials?

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