Small ribosomal subunit protein uS2
Details
- Name
- Small ribosomal subunit protein uS2
- Kind
- protein
- Synonyms
- 37 kDa laminin receptor precursor
- 37/67 kDa laminin receptor
- 37LRP
- 40S ribosomal protein SA
- 67 kDa laminin receptor
- 67LR
- Colon carcinoma laminin-binding protein
- LAMBR
- Laminin receptor 1
- Laminin-binding protein precursor p40
- LamR
- LAMR1
- LBP/p40
- LRP/LR
- Multidrug resistance-associated protein MGr1-Ag
- NEM/1CHD4
- Gene Name
- RPSA
- UniProtKB Entry
- P08865Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0016781|Small ribosomal subunit protein uS2 MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPR LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
- Number of residues
- 295
- Molecular Weight
- 32853.79
- Theoretical pI
- 4.51
- GO Classification
- FunctionsDNA binding / laminin binding / RNA bindingProcessesantiviral innate immune response / cytoplasmic translationComponentscytosolic ribosome / nucleoplasm
- General Function
- Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA
- Specific Function
- DNA binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016782|40S ribosomal protein SA (RPSA) ATGTCCGGAGCCCTTGATGTCCTGCAAATGAAGGAGGAGGATGTCCTTAAGTTCCTTGCA GCAGGAACCCACTTAGGTGGCACCAATCTTGACTTCCAGATGGAACAGTACATCTATAAA AGGAAAAGTGATGGCATCTATATCATAAATCTCAAGAGGACCTGGGAGAAGCTTCTGCTG GCAGCTCGTGCAATTGTTGCCATTGAAAACCCTGCTGATGTCAGTGTTATATCCTCCAGG AATACTGGCCAGGTTTGTGGAACAGTGAGGGCTGTGCTGAAGTTTGCTGCTGCCACTGGA GCCACTCCAATTGCTGGCCGCTTCACTCCTGGAACCTTCACTAACCAGATCCAGGCAGCC TTCCGGGAGCCACGGCTTCTTGTGGTTACTGACCCCAGGGCTGACCACCAGCCTCTCACG GAGGCATCTTATGTTAACCTACCTACCATTGCGCTGTGTAACACAGATTCTCCTCTGCGC TATGTGGACATTGCCATCCCATGCAACAACAAGGGAGCTCACTCAGTGGGTTTGATGTGG TGGATGCTGGCTCGGGAAGTTCTGCGCATGCGTGGCACCATTTCCCGTGAACACCCATGG GAGGTCATGCCTGATCTGTACTTCTACAGAGATCCTGAAGAGATTGAAAAAGAAGAGCAG GCTGCTGCTGAGAAGGCAGTGACCAAGGAGGAATTTCAGGGTGAATGGACTGCTCCCGCT CCTGAGTTCACTGCTACTCAGCCTGAGGTTGCAGACTGGTCTGAAGGTGTACAGGTGCCC TCTGTGCCTATTCAGCAATTCCCTACTGAAGACTGGAGCGCTCAGCCTGCCACGGAAGAC TGGTCTGCAGCTCCCACTGCTCAGGCCACTGAATGGGTAGGAGCAACCACTGACTGGTCT TAA
- Chromosome Location
- 3
- Locus
- 3p22.1
- External Identifiers
Resource Link UniProtKB ID P08865 UniProtKB Entry Name RSSA_HUMAN GenBank Gene ID J03799 GeneCard ID RPSA GenAtlas ID RPSA HGNC ID HGNC:6502 PDB ID(s) 3BCH, 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G18, 6G4S, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBD, 6YBW, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOK, 6ZON, 6ZP4, 6ZUO, 6ZV6, 6ZVH, 6ZVJ, 6ZXD, 6ZXE, 6ZXF, 6ZXG, 6ZXH, 7A09, 7K5I, 7QP6, 7QP7, 7QVP, 7R4X, 7TQL, 7WTV, 7WTW, 7WTX, 7WTZ, 7WU0, 7XNX, 7XNY, 8G5Y, 8G5Z, 8G60, 8G61, 8G6J, 8GLP, 8IFD, 8IFE, 8JDJ, 8JDK, 8JDL, 8JDM, 8OZ0, 8PPK, 8PPL, 8QOI, 8T4S, 8XXL, 8XXM, 8XXN, 8Y0W, 8Y0X KEGG ID hsa:3921 NCBI Gene ID 3921 - General References
- Yow HK, Wong JM, Chen HS, Lee CG, Davis S, Steele GD Jr, Chen LB: Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. Proc Natl Acad Sci U S A. 1988 Sep;85(17):6394-8. [Article]
- Van den Ouweland AM, Van Duijnhoven HL, Deichmann KA, Van Groningen JJ, de Leij L, Van de Ven WJ: Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes. Nucleic Acids Res. 1989 May 25;17(10):3829-43. [Article]
- Satoh K, Narumi K, Sakai T, Abe T, Kikuchi T, Matsushima K, Sindoh S, Motomiya M: Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung. Cancer Lett. 1992 Mar 15;62(3):199-203. [Article]
- Jackers P, Minoletti F, Belotti D, Clausse N, Sozzi G, Sobel ME, Castronovo V: Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3. Oncogene. 1996 Aug 1;13(3):495-503. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur J Biochem. 1996 Jul 1;239(1):144-9. [Article]
- Selvamurugan N, Eliceiri GL: The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene. Genomics. 1995 Nov 20;30(2):400-1. [Article]
- Wewer UM, Liotta LA, Jaye M, Ricca GA, Drohan WN, Claysmith AP, Rao CN, Wirth P, Coligan JE, Albrechtsen R, et al.: Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7137-41. [Article]
- Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC: A map of 75 human ribosomal protein genes. Genome Res. 1998 May;8(5):509-23. [Article]
- Terranova VP, Rao CN, Kalebic T, Margulies IM, Liotta LA: Laminin receptor on human breast carcinoma cells. Proc Natl Acad Sci U S A. 1983 Jan;80(2):444-8. [Article]
- Castronovo V, Taraboletti G, Sobel ME: Functional domains of the 67-kDa laminin receptor precursor. J Biol Chem. 1991 Oct 25;266(30):20440-6. [Article]
- Wang KS, Kuhn RJ, Strauss EG, Ou S, Strauss JH: High-affinity laminin receptor is a receptor for Sindbis virus in mammalian cells. J Virol. 1992 Aug;66(8):4992-5001. [Article]
- Cioce V, Margulies IM, Sobel ME, Castronovo V: Interaction between the 67 kilodalton metastasis-associated laminin receptor and laminin. Kidney Int. 1993 Jan;43(1):30-7. [Article]
- Ludwig GV, Kondig JP, Smith JF: A putative receptor for Venezuelan equine encephalitis virus from mosquito cells. J Virol. 1996 Aug;70(8):5592-9. [Article]
- Rieger R, Edenhofer F, Lasmezas CI, Weiss S: The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells. Nat Med. 1997 Dec;3(12):1383-8. [Article]
- Buto S, Tagliabue E, Ardini E, Magnifico A, Ghirelli C, van den Brule F, Castronovo V, Colnaghi MI, Sobel ME, Menard S: Formation of the 67-kDa laminin receptor by acylation of the precursor. J Cell Biochem. 1998 Jun 1;69(3):244-51. [Article]
- Ardini E, Pesole G, Tagliabue E, Magnifico A, Castronovo V, Sobel ME, Colnaghi MI, Menard S: The 67-kDa laminin receptor originated from a ribosomal protein that acquired a dual function during evolution. Mol Biol Evol. 1998 Aug;15(8):1017-25. [Article]
- Sato M, Saeki Y, Tanaka K, Kaneda Y: Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system. Biochem Biophys Res Commun. 1999 Mar 16;256(2):385-90. [Article]
- Kazmin DA, Hoyt TR, Taubner L, Teintze M, Starkey JR: Phage display mapping for peptide 11 sensitive sequences binding to laminin-1. J Mol Biol. 2000 May 5;298(3):431-45. [Article]
- Gauczynski S, Peyrin JM, Haik S, Leucht C, Hundt C, Rieger R, Krasemann S, Deslys JP, Dormont D, Lasmezas CI, Weiss S: The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein. EMBO J. 2001 Nov 1;20(21):5863-75. [Article]
- Thepparit C, Smith DR: Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor. J Virol. 2004 Nov;78(22):12647-56. [Article]
- Kim K, Li L, Kozlowski K, Suh HS, Cao W, Ballermann BJ: The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation. Biochem Biophys Res Commun. 2005 Dec 23;338(3):1327-34. Epub 2005 Oct 25. [Article]
- Kim KJ, Chung JW, Kim KS: 67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells. J Biol Chem. 2005 Jan 14;280(2):1360-8. Epub 2004 Oct 29. [Article]
- Akache B, Grimm D, Pandey K, Yant SR, Xu H, Kay MA: The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. J Virol. 2006 Oct;80(19):9831-6. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
- Jamieson KV, Wu J, Hubbard SR, Meruelo D: Crystal structure of the human laminin receptor precursor. J Biol Chem. 2008 Feb 8;283(6):3002-5. Epub 2007 Dec 6. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Tigapotide investigational unknown target Details Copper approved, investigational unknown target Details Paromomycin approved, investigational yes target inhibitor Details