DNA repair nuclease/redox regulator APEX1

BE0002414ProteinHumansAPEX1

Multifunctional protein that plays a central role in the cellular response to oxidative stress. It is acted on by 2 drugs in DrugBank.

Gene name
APEX1
UniProtKB entry
P27695Swiss-Prot
Cellular location
Nucleus
Residues / weight
318 residues · 35,554 Da
Also known as
3.1.11.2 · 3.1.21.- · AP endonuclease 1 · APE · APE-1

Resolves to

Protein
UniProtP27695UniProt nameAPEX1_HUMAN
Gene
HGNCHGNC:587NCBI Gene328GeneCardsAPEX1
Pharmacology
KEGGhsa:328
Structure
PDB1BIXPDB1CQGPDB1CQH
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA repair nuclease/redox regulator APEX1, and which indications are they being tested in?

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