Interleukin-13 receptor subunit alpha-2

Details

Kind

protein

Synonyms

IL-13 receptor subunit alpha-2
IL-13R subunit alpha-2
IL-13R-alpha-2
IL-13RA2
IL13R
Interleukin-13-binding protein

Gene Name

IL13RA2

UniProtKB Entry

Q14627Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0011732|Interleukin-13 receptor subunit alpha-2
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD
HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ
SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH
ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP
PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE
TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG
LLLRKPNTYPKMIPEFFCDT

Number of residues

380

Molecular Weight

44176.065

Theoretical pI

4.58

GO Classification

Functions

cytokine binding

Components

external side of plasma membrane / extracellular region / receptor complex

General Function

Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation (PubMed:11861389, PubMed:17030238). Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1 (PubMed:16327802)

Specific Function

cytokine binding

Pfam Domain Function

IL6Ra-bind (PF09240)

Signal Regions

1-26

Transmembrane Regions

344-363

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0011733|Interleukin-13 receptor subunit alpha-2 (IL13RA2)
ATGGCTTTCGTTTGCTTGGCTATCGGATGCTTATATACCTTTCTGATAAGCACAACATTT
GGCTGTACTTCATCTTCAGACACCGAGATAAAAGTTAACCCTCCTCAGGATTTTGAGATA
GTGGATCCCGGATACTTAGGTTATCTCTATTTGCAATGGCAACCCCCACTGTCTCTGGAT
CATTTTAAGGAATGCACAGTGGAATATGAACTAAAATACCGAAACATTGGTAGTGAAACA
TGGAAGACCATCATTACTAAGAATCTACATTACAAAGATGGGTTTGATCTTAACAAGGGC
ATTGAAGCGAAGATACACACGCTTTTACCATGGCAATGCACAAATGGATCAGAAGTTCAA
AGTTCCTGGGCAGAAACTACTTATTGGATATCACCACAAGGAATTCCAGAAACTAAAGTT
CAGGATATGGATTGCGTATATTACAATTGGCAATATTTACTCTGTTCTTGGAAACCTGGC
ATAGGTGTACTTCTTGATACCAATTACAACTTGTTTTACTGGTATGAGGGCTTGGATCAT
GCATTACAGTGTGTTGATTACATCAAGGCTGATGGACAAAATATAGGATGCAGATTTCCC
TATTTGGAGGCATCAGACTATAAAGATTTCTATATTTGTGTTAATGGATCATCAGAGAAC
AAGCCTATCAGATCCAGTTATTTCACTTTTCAGCTTCAAAATATAGTTAAACCTTTGCCG
CCAGTCTATCTTACTTTTACTCGGGAGAGTTCATGTGAAATTAAGCTGAAATGGAGCATA
CCTTTGGGACCTATTCCAGCAAGGTGTTTTGATTATGAAATTGAGATCAGAGAAGATGAT
ACTACCTTGGTGACTGCTACAGTTGAAAATGAAACATACACCTTGAAAACAACAAATGAA
ACCCGACAATTATGCTTTGTAGTAAGAAGCAAAGTGAATATTTATTGCTCAGATGACGGA
ATTTGGAGTGAGTGGAGTGATAAACAATGCTGGGAAGGTGAAGACCTATCGAAGAAAACT
TTGCTACGTTTCTGGCTACCATTTGGTTTCATCTTAATATTAGTTATATTTGTAACCGGT
CTGCTTTTGCGTAAGCCAAACACCTACCCAAAAATGATTCCAGAATTTTTCTGTGATACA
TGA

Chromosome Location

Locus

Xq23

External Identifiers

Resource	Link
UniProtKB ID	Q14627
UniProtKB Entry Name	I13R2_HUMAN
GenBank Gene ID	X95302
GeneCard ID	IL13RA2
GenAtlas ID	IL13RA2
HGNC ID	HGNC:5975
PDB ID(s)	3LB6
KEGG ID	hsa:3598
NCBI Gene ID	3598

General References

Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P: Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J Biol Chem. 1996 Jul 12;271(28):16921-6. [Article]
Guo J, Apiou F, Mellerin MP, Lebeau B, Jacques Y, Minvielle S: Chromosome mapping and expression of the human interleukin-13 receptor. Genomics. 1997 May 15;42(1):141-5. [Article]
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Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
AER001	investigational	unknown	target		Details