NADPH oxidase organizer 1

BE0002423ProteinHumansNOXO1

Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. It is acted on by 1 drug in DrugBank.

Gene name
NOXO1
UniProtKB entry
Q8NFA2Swiss-Prot
Cellular location
Cell membrane
Residues / weight
376 residues · 41,252 Da
Also known as
NADPH oxidase regulatory protein · Nox organizer 1 · Nox-organizing protein 1 · P41NOX · SH3 and PX domain-containing protein 5

Resolves to

Protein
UniProtQ8NFA2UniProt nameNOXO1_HUMAN
Gene
HGNCHGNC:19404NCBI Gene124056GenBank25573148GeneCardsNOXO1
Pharmacology
KEGGhsa:124056
Structure
PDB2L73
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NADPH oxidase organizer 1, and which indications are they being tested in?

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