Atrial natriuretic peptide receptor 3

BE0002426ProteinHumansNPR3

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. It is acted on by 3 drugs in DrugBank.

Gene name
NPR3
UniProtKB entry
P17342Swiss-Prot
Cellular location
Cell membrane
Residues / weight
541 residues · 59,807 Da
Also known as
ANP-C · ANPR-C · ANPRC · Atrial natriuretic peptide clearance receptor · Atrial natriuretic peptide receptor type C

Resolves to

Protein
UniProtP17342UniProt nameANPRC_HUMAN
Gene
HGNCHGNC:7945NCBI Gene4883GeneCardsNPR3
Pharmacology
IUPHAR/GtoPdb1749KEGGhsa:4883
Structure
PDB1JDNPDB1JDPPDB1YK0
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Atrial natriuretic peptide receptor 3, how selective are they, and which programs against it are still in active trials?

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