Telomerase reverse transcriptase

BE0002449ProteinHumansTERT

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It is acted on by 16 drugs in DrugBank.

Gene name
TERT
UniProtKB entry
O14746Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
1,132 residues · 126,995 Da
Also known as
2.7.7.49 · EST2 · HEST2 · TCS1 · Telomerase catalytic subunit

Resolves to

Protein
UniProtO14746UniProt nameTERT_HUMAN
Gene
HGNCHGNC:11730NCBI Gene7015GeneCardsTERT
Pharmacology
KEGGhsa:7015
Structure
PDB2BCKPDB4B18PDB4MNQ
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Telomerase reverse transcriptase, how selective are they, and which programs against it are still in active trials?

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