Ribonucleoside-diphosphate reductase subunit M2

BE0002450ProteinHumansRRM2

Provides the precursors necessary for DNA synthesis. It is acted on by 17 drugs in DrugBank.

Gene name
RRM2
UniProtKB entry
P31350Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
389 residues · 44,877 Da
Also known as
1.17.4.1 · Ribonucleotide reductase small chain · Ribonucleotide reductase small subunit · RR2

Resolves to

Protein
UniProtP31350UniProt nameRIR2_HUMAN
Gene
HGNCHGNC:10452NCBI Gene6241GeneCardsRRM2
Pharmacology
IUPHAR/GtoPdb2631KEGGhsa:6241
Structure
PDB2UW2PDB3OLJPDB3VPM
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ribonucleoside-diphosphate reductase subunit M2, how selective are they, and which programs against it are still in active trials?

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