Telomerase-binding protein EST1A

BE0002478ProteinHumansSMG6

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). It is acted on by 1 drug in DrugBank.

Gene name
SMG6
UniProtKB entry
Q86US8Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
1,419 residues · 160,460 Da
Also known as
3.1.-.- · C17orf31 · EST1A · Ever shorter telomeres 1A · hEST1A

Resolves to

Protein
UniProtQ86US8UniProt nameEST1A_HUMAN
Gene
HGNCHGNC:17809NCBI Gene23293GeneCardsSMG6
Pharmacology
KEGGhsa:23293
Structure
PDB2DOKPDB2HWWPDB2HWX
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Telomerase-binding protein EST1A, how selective are they, and which programs against it are still in active trials?

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