Telomerase-binding protein EST1A
Details
- Name
- Telomerase-binding protein EST1A
- Kind
- protein
- Synonyms
- 3.1.-.-
- C17orf31
- EST1A
- Ever shorter telomeres 1A
- hEST1A
- hSmg5/7a
- KIAA0732
- Nonsense mediated mRNA decay factor SMG6
- Smg-6 homolog
- Gene Name
- SMG6
- UniProtKB Entry
- Q86US8Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004866|Telomerase-binding protein EST1A MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLR NKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQES FPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGS AKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSS TDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVN SAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTD DEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVK DPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTR RKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKK STFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFS EECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLK ELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYK DPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCG QEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGED DIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLFLVPDTNGFIDHLA SLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFES RDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDFMPASKEEPI RLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG
- Number of residues
- 1419
- Molecular Weight
- 160460.34
- Theoretical pI
- 7.03
- GO Classification
- FunctionsDNA polymerase binding / ribonucleoprotein complex binding / RNA binding / RNA endonuclease activity / telomerase RNA bindingProcessesnegative regulation of telomere capping / regulation of telomerase activity / regulation of telomere maintenance / regulation of telomere maintenance via telomerase
- General Function
- Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini (PubMed:19179534). May have a general role in telomere regulation (PubMed:12676087, PubMed:12699629). Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629). Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (PubMed:12676087, PubMed:12699629)
- Specific Function
- DNA polymerase binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus, nucleolus
- Gene sequence
>lcl|BSEQ0011773|Telomerase-binding protein EST1A (SMG6) ATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAG CACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTT GCAGTACACAACTCCCAGCTGAAAGACTGCTTCTCGGAGGAGTGCCGCTCTGTGATCCAG GAACAAGCCGCAGCTCTGGGCTTGGCCATGTTTTCTCTACTGGTCCGCCGCTGCACCTGC TTACTTAAGGAGTCCGCCAAAGCTCAGCTGTCCTCTCCTGAGGACCAGGATGACCAAGAC GACATCAAGGTGTCTTCCTTTGTCCCGGACCTGAAGGAGCTGCTCCCCAGTGTCAAAGTC TGGTCAGATTGGATGCTCGGCTACCCGGACACCTGGAATCCTCCTCCCACATCCCTGGAT CTGCCCTCGCATGTTGCTGTGGATGTATGGTCGACGCTGGCTGATTTCTGTAACATACTG ACTGCAGTGAATCAGTCTGAGGTGCCACTGTACAAGGACCCGGATGATGACCTCACCCTT CTTATCCTGGAAGAGGATCGGCTTCTCTCGGGCTTTGTCCCCTTGCTGGCTGCCCCTCAG GACCCCTGCTACGTGGAGAAAACCTCGGATAAGGTTATTGCAGCTGACTGCAAAAGGGTC ACAGTGCTGAAGTATTTTCTGGAAGCCCTTTGTGGACAAGAAGAGCCTCTGCTGGCATTC AAGGGTGGAAAGTATGTGTCAGTGGCACCCGTCCCAGACACCATGGGAAAGGAAATGGGA AGCCAAGAGGGAACACGACTGGAAGATGAGGAGGAGGATGTGGTGATTGAAGACTTTGAG GAAGATTCAGAGGCTGAAGGCAGCGGAGGCGAGGATGACATCAGGGAGCTTCGGGCCAAG AAGCTGGCTCTGGCCAGGAAGATAGCTGAGCAGCAGCGTCGCCAGGAAAAGATCCAGGCT GTCCTGGAGGACCACAGTCAGATGAGGCAGATGGAGCTCGAAATCAGACCTTTGTTCCTC GTACCAGACACCAACGGCTTCATTGACCACCTGGCCAGTCTGGCGCGGCTGCTGGAGAGC AGGAAGTACATCCTGGTGGTGCCCCTCATCGTGATCAATGAGCTGGACGGCCTGGCCAAG GGGCAGGAGACAGACCACCGGGCTGGGGGCTACGCCCGTGTGGTACAAGAGAAGGCCCGC AAGTCCATCGAGTTCCTCGAGCAGCGATTCGAGAGTCGGGACTCTTGCCTGCGAGCCCTG ACCAGCCGTGGCAATGAACTCGAATCCATCGCCTTCCGCAGTGAGGACATCACTGGCCAG CTGGGTAACAACGATGATCTCATCCTGTCCTGCTGCCTCCACTACTGCAAAGACAAGGCT AAGGACTTCATGCCCGCCAGCAAAGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTG TTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGAC ATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGA
- Chromosome Location
- 17
- Locus
- 17p13.3
- External Identifiers
Resource Link UniProtKB ID Q86US8 UniProtKB Entry Name EST1A_HUMAN GenBank Gene ID AY145883 GeneCard ID SMG6 GenAtlas ID SMG6 HGNC ID HGNC:17809 PDB ID(s) 2DOK, 2HWW, 2HWX, 4UM2, 8RXB KEGG ID hsa:23293 NCBI Gene ID 23293 - General References
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