Prostaglandin E synthase 3

BE0002480ProteinHumansPTGES3

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). It is acted on by 3 drugs in DrugBank.

Gene name
PTGES3
UniProtKB entry
Q15185Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
160 residues · 18,697 Da
Also known as
5.3.99.3 · cPGES · Cytosolic prostaglandin E2 synthase · Hsp90 co-chaperone · P23

Resolves to

Protein
UniProtQ15185UniProt nameTEBP_HUMAN
Gene
HGNCHGNC:16049NCBI Gene10728GeneCardsPTGES3
Pharmacology
KEGGhsa:10728
Structure
PDB1EJFPDB7KRJPDB7L7I
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prostaglandin E synthase 3, how selective are they, and which programs against it are still in active trials?

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