Hypoxia-inducible factor 1-alpha inhibitor

BE0002503ProteinHumansHIF1AN

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). It is acted on by 2 drugs in DrugBank.

Gene name
HIF1AN
UniProtKB entry
Q9NWT6Swiss-Prot
Cellular location
Nucleus
Residues / weight
349 residues · 40,285 Da
Also known as
1.14.11.30 · 1.14.11.n4 · Factor inhibiting HIF-1 · FIH-1 · FIH1

Resolves to

Protein
UniProtQ9NWT6UniProt nameHIF1N_HUMAN
Gene
HGNCHGNC:17113NCBI Gene55662GeneCardsHIF1AN
Pharmacology
KEGGhsa:55662
Structure
PDB1H2KPDB1H2LPDB1H2M
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Hypoxia-inducible factor 1-alpha inhibitor, and which indications are they being tested in?

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