D-3-phosphoglycerate dehydrogenase
Details
- Name
- D-3-phosphoglycerate dehydrogenase
- Kind
- protein
- Synonyms
- 1.1.1.95
- 2-oxoglutarate reductase
- PGDH
- Gene Name
- serA
- UniProtKB Entry
- P9WNX3Swiss-Prot
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- NCBI Taxonomy ID
- 83332
- Amino acid sequence
>lcl|BSEQ0051136|D-3-phosphoglycerate dehydrogenase MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVL AAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAA DASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAA QLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAA LADAITGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVR LALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEE VEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVGAD GSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVN IQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
- Number of residues
- 528
- Molecular Weight
- 54553.635
- Theoretical pI
- Not Available
- GO Classification
- FunctionsNAD binding / phosphoglycerate dehydrogenase activityProcessesgrowth / L-serine biosynthetic processComponentscell wall / plasma membrane
- General Function
- Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
- Specific Function
- NAD binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051137|D-3-phosphoglycerate dehydrogenase (serA) GTGAGCCTGCCTGTTGTGTTGATCGCCGACAAACTTGCCCCATCAACGGTTGCCGCCTTG GGAGATCAGGTCGAGGTGCGCTGGGTTGACGGTCCGGACCGAGACAAGCTGCTGGCCGCG GTGCCCGAAGCGGACGCGCTGCTGGTGCGATCGGCCACCACGGTTGACGCCGAGGTGCTG GCCGCCGCCCCCAAGCTCAAGATCGTCGCGCGCGCCGGCGTCGGGCTGGACAACGTCGAC GTGGACGCCGCGACGGCCCGCGGCGTGCTGGTGGTCAACGCCCCGACGTCGAACATCCAC AGCGCCGCGGAGCATGCGCTGGCGCTGCTGCTGGCCGCCTCACGCCAGATTCCGGCGGCC GACGCGTCGCTGCGCGAGCACACCTGGAAGCGTTCGTCGTTTTCCGGTACCGAGATCTTC GGCAAAACCGTCGGCGTGGTGGGTCTGGGCCGCATCGGGCAGTTGGTCGCCCAGCGGATC GCTGCGTTCGGCGCTTACGTCGTCGCCTATGACCCGTACGTTTCGCCGGCCCGTGCGGCG CAGCTGGGCATCGAACTGCTGTCCCTGGACGACCTGCTGGCCCGCGCCGATTTCATCTCG GTGCACCTACCGAAAACACCGGAGACGGCGGGACTGATCGACAAGGAGGCGCTGGCGAAG ACCAAGCCGGGCGTCATCATCGTCAACGCCGCGCGCGGCGGCCTGGTGGACGAGGCGGCA CTGGCCGACGCGATCACCGGCGGCCACGTGCGGGCGGCCGGTCTGGACGTGTTCGCCACC GAACCGTGCACCGACAGCCCGCTGTTCGAGCTGGCACAGGTGGTGGTCACACCGCATCTG GGTGCGTCCACCGCGGAGGCGCAGGACCGGGCGGGCACCGACGTCGCCGAGAGCGTGCGG CTGGCCCTGGCAGGGGAATTCGTGCCCGACGCGGTCAACGTCGGCGGCGGAGTGGTCAAC GAGGAGGTGGCGCCCTGGCTGGATCTGGTGCGTAAGCTCGGCGTGCTGGCGGGTGTGTTG TCCGACGAACTGCCGGTGTCGTTGTCGGTGCAGGTGCGCGGTGAGCTGGCCGCCGAAGAG GTTGAGGTGCTGCGCCTTTCGGCGCTGCGCGGCCTGTTCTCGGCGGTGATCGAGGATGCG GTGACATTTGTCAACGCACCGGCATTGGCCGCCGAACGTGGCGTCACCGCCGAGATCTGT AAGGCCTCGGAAAGCCCCAACCACCGCAGCGTCGTCGACGTTCGCGCGGTCGGCGCGGAC GGTTCGGTGGTGACCGTCTCGGGCACGCTGTATGGCCCACAGCTGTCGCAGAAGATCGTG CAGATCAACGGCCGCCACTTTGATCTGCGCGCCCAGGGGATCAACCTGATCATCCACTAC GTCGACCGGCCGGGAGCGCTGGGCAAGATCGGCACGTTGCTGGGGACGGCCGGGGTGAAT ATCCAGGCCGCGCAGCTCTCCGAAGACGCCGAAGGCCCGGGCGCGACGATTCTGCTGCGG CTGGACCAAGACGTGCCCGACGACGTGCGGACGGCGATCGCGGCGGCGGTGGACGCCTAC AAGCTCGAGGTTGTCGATCTGTCGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WNX3 UniProtKB Entry Name SERA_MYCTU PDB ID(s) 1YGY, 3DC2, 3DDN KEGG ID mtu:Rv2996c NCBI Gene ID 887154 - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-tartaric acid experimental unknown target Details