D-3-phosphoglycerate dehydrogenase

BE0002504ProteinMycobacterium tuberculosisserA

Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. It is acted on by 1 drug in DrugBank.

Gene name
serA
UniProtKB entry
P9WNX3Swiss-Prot
Residues / weight
528 residues · 54,554 Da
Also known as
1.1.1.95 · 2-oxoglutarate reductase · PGDH

Resolves to

Protein
UniProtP9WNX3UniProt nameSERA_MYCTU
Gene
NCBI Gene887154
Pharmacology
KEGGmtu:Rv2996c
Structure
PDB1YGYPDB3DC2PDB3DDN
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on D-3-phosphoglycerate dehydrogenase, and which indications are they being tested in?

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