Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Details

Name
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Kind
protein
Synonyms
  • 2.3.1.129
  • UDP-N-acetylglucosamine acyltransferase
Gene Name
lpxA
UniProtKB Entry
O25927Swiss-Prot
Organism
Helicobacter pylori (strain ATCC 700392 / 26695)
NCBI Taxonomy ID
85962
Amino acid sequence
>lcl|BSEQ0011787|Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
MSKIAKTAIISPKAEINKGVEIGEFCVIGDGVKLDEGVKLHNNVTLQGHTFVGKNTEIFP
FAVLGTQPQDLKYKGEYSELIIGEDNLIREFCMINPGTEGGIKKTLIGDKNLLMAYVHVA
HDCVIGSHCILANGVTLAGHIEIGDYVNIGGLTAIHQFVRIAKGCMIAGKSALGKDVPPY
CTVEGNRAFIRGLNRHRMRQLLESKDIDFIYALYKRLFRPIPSLRESAKLELEEHANNPF
VKEICSFILESSRGVAYKSSEYSSEEKQEE
Number of residues
270
Molecular Weight
29855.195
Theoretical pI
6.99
GO Classification
Functions
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
Processes
lipid A biosynthetic process
Components
cytoplasm
General Function
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Specific Function
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011788|Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
ATGAGTAAGATTGCAAAAACAGCCATCATCTCTCCTAAAGCAGAGATTAATAAGGGCGTA
GAGATTGGGGAATTTTGCGTGATTGGAGATGGCGTCAAACTAGATGAAGGCGTGAAACTC
CACAACAATGTAACCTTACAAGGGCATACTTTCGTTGGGAAAAACACCGAAATTTTCCCT
TTTGCCGTGCTAGGCACACAGCCTCAAGATTTAAAATATAAGGGCGAATACAGCGAACTG
ATTATTGGAGAAGACAACCTTATTCGGGAATTTTGCATGATAAATCCCGGCACTGAAGGG
GGGATTAAAAAAACCCTTATTGGGGATAAAAACCTGCTCATGGCTTATGTGCATGTCGCT
CATGATTGCGTGATTGGAAGCCATTGTATTTTGGCTAATGGCGTAACTTTAGCAGGTCAT
ATTGAAATAGGCGATTATGTCAATATCGGCGGTCTTACCGCGATCCATCAGTTTGTGCGT
ATCGCTAAAGGGTGCATGATAGCCGGTAAGAGCGCTTTAGGCAAAGACGTGCCGCCTTAT
TGCACCGTAGAGGGCAATCGCGCTTTTATTAGGGGGTTAAACCGCCACCGGATGCGCCAA
TTATTAGAGAGTAAGGATATTGATTTTATTTATGCACTTTATAAAAGATTGTTCCGCCCT
ATCCCCTCTTTAAGAGAGAGCGCTAAATTAGAATTAGAAGAGCATGCCAATAACCCTTTT
GTGAAAGAGATTTGCTCTTTTATTTTAGAGAGTTCTAGGGGCGTGGCGTATAAGTCAAGC
GAATATTCTAGCGAAGAAAAACAAGAGGAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDO25927
UniProtKB Entry NameLPXA_HELPY
GenBank Gene IDAE000511
PDB ID(s)1J2Z
KEGG IDheo:C694_07095
NCBI Gene ID900308
General References
  1. Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [Article]
  2. Lee BI, Suh SW: Crystal structure of UDP-N-acetylglucosamine acyltransferase from Helicobacter pylori. Proteins. 2003 Nov 15;53(3):772-4. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
D-tartaric acidexperimentalunknowntargetDetails
2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOLexperimentalunknowntargetDetails