Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

BE0002505ProteinHelicobacter pylori (strain ATCC 700392 / 26695)lpxA

Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. It is acted on by 2 drugs in DrugBank.

Gene name
lpxA
UniProtKB entry
O25927Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
270 residues · 29,855 Da
Also known as
2.3.1.129 · UDP-N-acetylglucosamine acyltransferase

Resolves to

Protein
UniProtO25927UniProt nameLPXA_HELPY
Gene
NCBI Gene900308
Pharmacology
KEGGheo:C694_07095
Structure
PDB1J2Z
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, and which indications are they being tested in?

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