Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Details
- Name
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- Kind
- protein
- Synonyms
- 2.3.1.129
- UDP-N-acetylglucosamine acyltransferase
- Gene Name
- lpxA
- UniProtKB Entry
- O25927Swiss-Prot
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- NCBI Taxonomy ID
- 85962
- Amino acid sequence
>lcl|BSEQ0011787|Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase MSKIAKTAIISPKAEINKGVEIGEFCVIGDGVKLDEGVKLHNNVTLQGHTFVGKNTEIFP FAVLGTQPQDLKYKGEYSELIIGEDNLIREFCMINPGTEGGIKKTLIGDKNLLMAYVHVA HDCVIGSHCILANGVTLAGHIEIGDYVNIGGLTAIHQFVRIAKGCMIAGKSALGKDVPPY CTVEGNRAFIRGLNRHRMRQLLESKDIDFIYALYKRLFRPIPSLRESAKLELEEHANNPF VKEICSFILESSRGVAYKSSEYSSEEKQEE
- Number of residues
- 270
- Molecular Weight
- 29855.195
- Theoretical pI
- 6.99
- GO Classification
- Functionsacyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activityProcesseslipid A biosynthetic processComponentscytoplasm
- General Function
- Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
- Specific Function
- acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011788|Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA) ATGAGTAAGATTGCAAAAACAGCCATCATCTCTCCTAAAGCAGAGATTAATAAGGGCGTA GAGATTGGGGAATTTTGCGTGATTGGAGATGGCGTCAAACTAGATGAAGGCGTGAAACTC CACAACAATGTAACCTTACAAGGGCATACTTTCGTTGGGAAAAACACCGAAATTTTCCCT TTTGCCGTGCTAGGCACACAGCCTCAAGATTTAAAATATAAGGGCGAATACAGCGAACTG ATTATTGGAGAAGACAACCTTATTCGGGAATTTTGCATGATAAATCCCGGCACTGAAGGG GGGATTAAAAAAACCCTTATTGGGGATAAAAACCTGCTCATGGCTTATGTGCATGTCGCT CATGATTGCGTGATTGGAAGCCATTGTATTTTGGCTAATGGCGTAACTTTAGCAGGTCAT ATTGAAATAGGCGATTATGTCAATATCGGCGGTCTTACCGCGATCCATCAGTTTGTGCGT ATCGCTAAAGGGTGCATGATAGCCGGTAAGAGCGCTTTAGGCAAAGACGTGCCGCCTTAT TGCACCGTAGAGGGCAATCGCGCTTTTATTAGGGGGTTAAACCGCCACCGGATGCGCCAA TTATTAGAGAGTAAGGATATTGATTTTATTTATGCACTTTATAAAAGATTGTTCCGCCCT ATCCCCTCTTTAAGAGAGAGCGCTAAATTAGAATTAGAAGAGCATGCCAATAACCCTTTT GTGAAAGAGATTTGCTCTTTTATTTTAGAGAGTTCTAGGGGCGTGGCGTATAAGTCAAGC GAATATTCTAGCGAAGAAAAACAAGAGGAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O25927 UniProtKB Entry Name LPXA_HELPY GenBank Gene ID AE000511 PDB ID(s) 1J2Z KEGG ID heo:C694_07095 NCBI Gene ID 900308 - General References
- Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC: The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997 Aug 7;388(6642):539-47. [Article]
- Lee BI, Suh SW: Crystal structure of UDP-N-acetylglucosamine acyltransferase from Helicobacter pylori. Proteins. 2003 Nov 15;53(3):772-4. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-tartaric acid experimental unknown target Details 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL experimental unknown target Details