Phosphonoacetate hydrolase
Details
- Name
- Phosphonoacetate hydrolase
- Kind
- protein
- Synonyms
- 3.11.1.2
- Gene Name
- phnA
- UniProtKB Entry
- Q51782Swiss-Prot
- Organism
- Pseudomonas fluorescens
- NCBI Taxonomy ID
- 294
- Amino acid sequence
>lcl|BSEQ0022283|Phosphonoacetate hydrolase MTQLISVNSRSYRLSSAPTIVICVDGCEQEYINQAIQAGQAPFLAELTGFGTVLTGDCVV PSFTNPNNLSIVTGAPPSVHGICGNFFFDQETQEEVLMNDAKYLRAPTILAEMAKAGQLV AVVTAKDKLRNLLGHQLKGICFSAEKADQVNLEEHGVENILARVGMPVPSVYSADLSEFV FAAGLSLLTNERPDFMYLSTTDYVQHKHAPGTPEANAFYAMMDSYFKRYHEQGAIVAITA DHGMNAKTDAIGRPNILFLQDLLDAQYGAQRTRVLLPITDPYVVHHGALGSYATVYLRDA VPQRDAIDFLAGIAGVEAVLTRSQACQRFELPEDRIGDLVVLGERLTVLGSAADKHDLSG LTVPLRSHGGVSEQKVPLIFNRKLVGLDSPGRLRNFDIIDLALNHLA
- Number of residues
- 407
- Molecular Weight
- 44239.04
- Theoretical pI
- 5.37
- GO Classification
- Functionsmetal ion binding / phosphonoacetate hydrolase activityProcessesphosphonoacetate metabolic process
- General Function
- Specifically hydrolyzes phosphonoacetate. Does not have activity on other organophosphonates or acetates.
- Specific Function
- metal ion binding
- Pfam Domain Function
- Phosphodiest (PF01663)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0004924|1224 bp ATGACACAACTTATCAGCGTGAACTCGCGCTCCTATCGCCTGTCGTCGGCACCGACGATT GTTATCTGCGTCGACGGATGCGAGCAGGAATACATCAATCAAGCCATTCAAGCCGGACAG GCACCGTTTCTCGCCGAACTTACCGGCTTCGGCACAGTGTTGACTGGCGATTGCGTGGTG CCTTCGTTCACCAACCCGAACAATCTGTCGATCGTTACCGGGGCCCCGCCATCCGTTCAC GGTATTTGCGGCAACTTCTTTTTTGACCAGGAGACGCAAGAGGAGGTGTTGATGAACGAC GCGAAGTACCTTCGCGCGCCGACTATTCTTGCCGAGATGGCCAAAGCGGGCCAGCTCGTC GCCGTGGTGACCGCAAAGGACAAGTTGCGCAACTTGCTGGGGCATCAACTGAAAGGGATC TGTTTTTCCGCTGAAAAAGCCGACCAGGTGAATCTGGAGGAACACGGTGTCGAGAACATC CTGGCAAGAGTCGGCATGCCCGTGCCTTCGGTATACAGCGCAGACCTTTCCGAGTTCGTG TTTGCCGCCGGCCTCTCGTTGTTGACCAACGAACGCCCCGACTTCATGTACCTGTCCACT ACCGATTATGTACAACACAAACATGCGCCAGGCACACCCGAAGCCAATGCGTTCTACGCA ATGATGGACAGCTACTTCAAGCGTTATCACGAGCAAGGCGCGATCGTGGCGATTACGGCG GATCACGGCATGAATGCCAAGACCGATGCGATAGGTCGCCCCAACATCCTGTTTTTGCAA GACCTTCTCGATGCCCAATATGGCGCGCAGCGCACACGGGTATTACTGCCGATCACCGAC CCTTACGTAGTGCATCACGGCGCGCTGGGCTCTTACGCGACCGTGTACTTGCGCGATGCG GTACCGCAGCGCGATGCCATCGACTTTCTCGCAGGCATCGCCGGTGTCGAGGCAGTCTTG ACGCGTTCGCAGGCCTGCCAGCGATTCGAACTGCCCGAAGACCGGATTGGCGACCTGGTG GTACTCGGGGAACGACTGACGGTGCTTGGCAGTGCTGCCGACAAACACGACCTGTCCGGA CTGACGGTGCCCTTGCGTTCCCACGGTGGTGTATCGGAGCAGAAAGTGCCACTGATCTTC AACCGCAAGCTGGTCGGTCTCGACAGCCCCGGCCGACTGCGAAATTTCGACATTATCGAT CTCGCGCTCAACCATCTCGCTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q51782 UniProtKB Entry Name PHNHY_PSEFL GenBank Gene ID L49465 PDB ID(s) 1EI6 KEGG ID ag:AAC15507 - General References
- Kulakova AN, Kulakov LA, Quinn JP: Cloning of the phosphonoacetate hydrolase gene from Pseudomonas fluorescens 23F encoding a new type of carbon-phosphorus bond cleaving enzyme and its expression in Escherichia coli and Pseudomonas putida. Gene. 1997 Aug 11;195(1):49-53. [Article]
- Panas P, Ternan NG, Dooley JS, McMullan G: Detection of phosphonoacetate degradation and phnA genes in soil bacteria from distinct geographical origins suggest its possible biogenic origin. Environ Microbiol. 2006 May;8(5):939-45. [Article]
- McGrath JW, Wisdom GB, McMullan G, Larkin MJ, Quinn JP: The purification and properties of phosphonoacetate hydrolase, a novel carbon-phosphorus bond-cleavage enzyme from Pseudomonas fluorescens 23F. Eur J Biochem. 1995 Nov 15;234(1):225-30. [Article]
- McMullan G, Quinn JP: In vitro characterization of a phosphate starvation-independent carbon-phosphorus bond cleavage activity in Pseudomonas fluorescens 23F. J Bacteriol. 1994 Jan;176(2):320-4. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details D-tartaric acid experimental unknown target Details