Peptide deformylase

BE0002535ProteinStaphylococcus aureusdef

Removes the formyl group from the N-terminal Met of newly synthesized proteins. It is acted on by 10 drugs in DrugBank.

Gene name
def
UniProtKB entry
P68826Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
183 residues · 20,558 Da
Also known as
3.5.1.88 · def1 · PDF · pdf1 · Polypeptide deformylase

Resolves to

Protein
UniProtP68826UniProt nameDEF_STAAU
Structure
PDB1LM4PDB1LMHPDB1LQW
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptide deformylase, how selective are they, and which programs against it are still in active trials?

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