Aclacinomycin methylesterase RdmC

BE0002558ProteinStreptomyces purpurascensrdmC

Involved in the biosynthesis of the anthracycline aclacinomycin which is an aromatic polyketide antibiotic that exhibits high cytotoxicity and is widely applied in the chemotherapy of a variety of cancers. It is acted on by 2 drugs in DrugBank.

Gene name
rdmC
UniProtKB entry
Q54528Swiss-Prot
Residues / weight
298 residues · 31,792 Da
Also known as
3.1.1.95

Resolves to

Protein
UniProtQ54528UniProt nameRDMC_STREF
Pharmacology
KEGGag:AAA83422
Structure
PDB1Q0RPDB1Q0Z
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aclacinomycin methylesterase RdmC, and which indications are they being tested in?

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