Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

BE0002559ProteinHumansNDST1

Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:35137078, PubMed:9230113, PubMed:9744796). It is acted on by 1 drug in DrugBank.

Gene name
NDST1
UniProtKB entry
P52848Swiss-Prot
Cellular location
Golgi apparatus, trans-Golgi network membrane
Residues / weight
882 residues · 100,867 Da
Also known as
[Heparan sulfate]-glucosamine N-sulfotransferase 1 · Glucosaminyl N-deacetylase/N-sulfotransferase 1 · HSNST 1 · HSST · HSST1

Resolves to

Protein
UniProtP52848UniProt nameNDST1_HUMAN
Gene
HGNCHGNC:7680NCBI Gene3340GeneCardsNDST1
Pharmacology
KEGGhsa:3340
Structure
PDB1NSTPDB8CCYPDB8CD0
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, and which indications are they being tested in?

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