Group 1 truncated hemoglobin GlbN

BE0002564ProteinMycobacterium tuberculosisglbN

Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).sec(-1)) and a slow dissociation (0.2 sec(-1)) rate. It is acted on by 2 drugs in DrugBank.

Gene name
glbN
UniProtKB entry
P9WN25Swiss-Prot
Residues / weight
136 residues · 14,448 Da
Also known as
Hemoglobin-like protein HbN · Truncated hemoglobin

Resolves to

Protein
UniProtP9WN25UniProt nameTRHBN_MYCTU
Gene
NCBI Gene886402
Pharmacology
KEGGmtu:Rv1542c
Structure
PDB1IDRPDB1RTEPDB1S56
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Group 1 truncated hemoglobin GlbN, and which indications are they being tested in?

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